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KMID : 0370219850290040193
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Yakhak Hoeji
1985 Volume.29 No. 4 p.193 ~ p.198
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Tablet Formulation of Eutectic Mixture: Preparation of Tablet Containing Aspirin and Isopropylantipyrine
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김종국/Kim CK
최성옥/최한곤/Choi SO/Choi HG
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Abstract
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In formulation technology, the drugs forming eutectic mixture cause many pharmaceutical problems. In this study, the method to prevent such problems has been investigated. The combined drugs of aspirin and isopropylantipyrine forming eutectic mixtures were granulated by using three kinds of binders (PVP, HPMC, starch) and these granules were made into pellets by compacting them with various compressional forces. It was possible to select optimum conditions in granulating, tableting, etc. Disintegration time and dissolution pattern were investigated about this formulation, too.
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KEYWORD
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